{"dataset":{"id":"61287","dataset_id":"on008610","name":"FUS and Tactile Neuromodulation in NHP VPL - Electrophysiology","description":"This dataset contains intracranial electrophysiology recordings from the ventral posterolateral (VPL) thalamus of macaque monkeys, obtained using a NeuroNexus multi-site probe on a Blackrock Cerebus recording system. Recordings were made during focused ultrasound (FUS) neuromodulation targeted at either VPL or insular cortex, and during tactile stimulation of the contralateral hand. The dataset supports investigation of how transcranial focused ultrasound modulates spiking and local field potential activity in the primate thalamus.","owner_user_id":15,"status":"active","github_repo":"nemarDatasets/on008610","concept_doi":"10.82901/nemar.on008610","latest_version_doi":"10.82901/nemar.on008610.v1.0.0","created_at":"2026-09-08 20:00:56","updated_at":"2026-09-08 20:08:21","zenodo_concept_id":null,"is_sandbox":0,"visibility":"public","ezid_status":"public","enrichment_json":"{\n  \"version\": \"2.0\",\n  \"pipeline_stage\": \"validated\",\n  \"title\": \"FUS and Tactile Neuromodulation in NHP VPL - Electrophysiology\",\n  \"description\": \"This dataset contains intracranial electrophysiology recordings from the ventral posterolateral (VPL) thalamus of macaque monkeys, obtained using a NeuroNexus multi-site probe on a Blackrock Cerebus recording system. Recordings were made during focused ultrasound (FUS) neuromodulation targeted at either VPL or insular cortex, and during tactile stimulation of the contralateral hand. The dataset supports investigation of how transcranial focused ultrasound modulates spiking and local field potential activity in the primate thalamus.\",\n  \"methods_description\": \"Extracellular electrophysiology was recorded from VPL thalamus using a NeuroNexus V1x32-Edge single-shank probe (32 sites, 100 µm pitch) connected to a Blackrock Cerebus system with CerePlex Direct and CerePlex M headstage. Spike data were sampled at 30 kHz and LFP at 1 kHz. Raw Blackrock files were read using NPMK (openNSx, openNEV) in MATLAB and converted to NWB format using MatNWB.\",\n  \"license\": \"CC0\",\n  \"dataset_type\": \"raw\",\n  \"authors\": {\n    \"Ning Zheng\": {},\n    \"Pai-Feng Yang\": {},\n    \"M. Anthony Phipps\": {},\n    \"Jiro Kusunose\": {},\n    \"Arabinda Mishra\": {},\n    \"Jixin Xia\": {},\n    \"William Rodriguez\": {},\n    \"Allen T. Newton\": {},\n    \"Benoit M. Dawant\": {\n      \"orcid\": \"0000-0002-3804-8400\"\n    },\n    \"John C. Gore\": {},\n    \"Charles F. Caskey\": {\n      \"orcid\": \"0000-0003-4545-4842\"\n    },\n    \"Li Min Chen\": {\n      \"orcid\": \"0000-0001-9662-1925\"\n    }\n  },\n  \"keywords\": [\n    {\n      \"term\": \"electrophysiology\"\n    },\n    {\n      \"term\": \"focused ultrasound\"\n    },\n    {\n      \"term\": \"Thalamus\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D013788\"\n    },\n    {\n      \"term\": \"tactile stimulation\"\n    },\n    {\n      \"term\": \"macaque\"\n    },\n    {\n      \"term\": \"local field potential\"\n    },\n    {\n      \"term\": \"neuromodulation\"\n    }\n  ],\n  \"related_identifiers\": [\n    {\n      \"identifier\": \"10.1038/s41467-026-75826-8\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsSupplementTo\"\n    },\n    {\n      \"identifier\": \"https://github.com/nemarDatasets/on008610\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"https://nemar.org/dataset/on008610\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"10.18112/openneuro.ds008610.v1.0.0\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsDerivedFrom\"\n    }\n  ],\n  \"funding_references\": [\n    {\n      \"funder_name\": \"NIH/NINDS\",\n      \"award_number\": \"RF1 NS126144\"\n    },\n    {\n      \"funder_name\": \"NIH/NIBIB\",\n      \"award_number\": \"1U18EB02935\"\n    }\n  ],\n  \"resource_type_general\": \"Dataset\",\n  \"resource_type_specific\": \"iEEG Dataset\",\n  \"modalities\": [\n    \"ieeg\"\n  ],\n  \"sizes\": [\n    \"5.07 GB (66 files)\"\n  ],\n  \"formats\": [\n    \".json\",\n    \".md\",\n    \".nwb\",\n    \".tsv\",\n    \".yml\"\n  ],\n  \"source_hash\": \"e5e3bcee6cbe82f6248366cb9e87fc18db32599ee119bf59d64f1eb7008bdebb\"\n}","last_activity_at":"2026-09-08 20:00:56","source":"openneuro","source_id":"ds008610","subject_count":2,"modalities":"ieeg","age_min":15,"age_max":19,"file_size":5440786324,"total_files":355,"tasks":"FUS,Tactile","metadata_columns_error":null,"staleness_warn_stage":null,"staleness_admin_notified_at":null,"authors":"Ning Zheng, Pai-Feng Yang, M. Anthony Phipps, Jiro Kusunose, Arabinda Mishra, Jixin Xia, William Rodriguez, Allen T. Newton, Benoit M. Dawant, John C. Gore, Charles F. Caskey, Li Min Chen","license":"CC0","readme":"[![DOI](https://img.shields.io/badge/DOI-10.82901%2Fnemar.on008610-blue)](https://doi.org/10.82901/nemar.on008610)\n\n# Raw Macaque Electrophysiology Dataset\n\n## Overview\nThis dataset contains intracranial electrophysiology recordings from macaque VPL thalamus, acquired with a NeuroNexus V1x32-Edge (Vector Array) single-shank probe (32 sites, 100 µm pitch, 177 µm² iridium sites) on a Blackrock Cerebus system, during two conditions:\n\n- Focused ultrasound (FUS) neuromodulation, with sonication targeted at either:\n  - VPL thalamus (co-located with the recording array), or\n  - insular cortex (recording remains in VPL)\n- Tactile stimulation of the hand contralateral to the recording hemisphere (right-hemisphere VPL array → left-hand stimulation, unless a session notes otherwise)\n\nFUS target (VPL vs insular cortex) and tactile stimulation side are recorded in each run’s `events.tsv` `stim_site` column—treat that as the authoritative per-trial record.\n\nThe data support the following publication:\nZheng, N., Yang, P.F., Phipps, M.A. et al. Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus. *Nat Commun* (2026). https://doi.org/10.1038/s41467-026-75826-8\n\n## Subjects\nSpecies: *Macaca fascicularis* and *Macaca mulatta*  \nSubject identifiers have been anonymized.  \nAdditional subject information is provided in `participants.tsv`.\n\n## Experimental design\nExtracellular electrophysiology was recorded from: VPL  \nFocused ultrasound was targeted to: VPL or insular cortex  \n\nThe experiment included the following conditions:\n- Focused ultrasound stimulation\n- Tactile stimulation\n\nEvent timing and stimulation parameters are provided in the corresponding `events.tsv` files.\n\n## Electrophysiology acquisition\nRecording system: Blackrock Microsystems  \nRecording hardware: CerePlex Direct with CerePlex M headstage  \nElectrode/probe: NeuroNexus V1x32-Edge  \nNumber of channels: 32  \nSampling frequency: 30 kHz (spikes), 1 kHz (LFP)  \nRecording hemisphere: Right  \nRecording location: VPL  \n\n## Data format\nRaw Blackrock files were read with NPMK (`openNSx`, `openNEV`) in MATLAB and written to NWB using MatNWB.\n\nFile types may include:\n- `.nwb`: raw electrophysiology recording and metadata\n- `.tsv`: participant, channel, electrode, and event tables\n- `.json`: metadata describing corresponding files\n\n## Data included\nsub-01:\n- Spikes dataset: FUS stimulation in VPL (`ses-ieeg01`)\n- LFP dataset: FUS stimulation in VPL (`ses-ieeg02`)\n- Tactile stimulation (left hand) (`ses-ieeg03`)\n\nsub-02:\n- Spikes dataset: FUS stimulation in VPL (`ses-ieeg01`)\n- LFP dataset: FUS stimulation in VPL (`ses-ieeg02`)\n- Spikes dataset: FUS stimulation in insular cortex (`ses-ieeg03`)\n- Tactile stimulation (left hand) (`ses-ieeg04`)\n\n## Funding\nThis work was supported by NIH grants:\n- NINDS RF1 NS126144\n- NIBIB 1U18EB02935\n\n## Contact\nLi Min Chen  \nVanderbilt University Institute of Imaging Science, Vanderbilt University  \nlimin.chen@vanderbilt.edu\n\nLi Min Chen\nDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center\nlimin.chen@vumc.org\n\n## License\nCC0","bids_version":"1.9.0","sessions_count":4,"publish_date":null,"embedding_dirty":0,"license_tier":"public","zarr_status":null,"zarr_converted_at":null,"zarr_store_count":null,"zarr_index_etag":null,"zarr_source_commit":null,"archive_status":"ready","archive_size":830737919,"archive_retry_count":0,"records_status":"ready","archive_skip_reason":null,"zarr_errors":null,"zarr_failure_count":null,"zarr_deterministic":null,"zarr_failed_at":null,"num_dataset_citations":0,"num_datapaper_citations":0,"n_channels":null,"electrode_system":null,"has_hed":0,"hed_version":null,"is_exemplar":0,"bytes_present":5440434932,"data_complete":1,"withdrawn_at":null,"withdrawn_reason":null,"archive_complete":1,"archive_absent_files":0,"archive_declared_files":355,"zarr_pool_breaks":null,"total_recording_duration":null,"recording_duration_min":null,"recording_duration_max":null,"recording_count":null,"recordings_unavailable":null,"recordings_measured":null,"channel_count_min":null,"channel_count_max":null,"sampling_frequency":null,"power_line_frequency":null,"eeg_reference":null,"placement_scheme":null,"sweep_stamps":"{\"enrichment_updated_at\":\"2026-09-08 20:07:55\",\"metadata_updated_at\":\"2026-09-08 20:08:20\",\"records_checked_at\":\"2026-09-08 20:10:03\",\"archive_checked_at\":\"2026-09-08 20:10:51\"}","participants":2,"num_citations":0,"latest_version":"v1.0.0","zarr_verify_status":null,"zarr_verified_at":null,"owner_username":"nemarAdmin","owner_github":"nemarAdmin","file_size_formatted":"5.07 GB","zarr_data_failures":null,"zarr_index_url":null,"attestation_deposit_type":null,"attestation_key_status":null,"attestation_deidentified":null,"attestation_no_duplicate":null,"attestation_upstream_source":null,"attestation_accepted_at":null}}