{"dataset":{"id":"61148","dataset_id":"on006065","name":"TSS_iEEG","description":"This dataset comprises intracranial EEG (iEEG) recordings from 7 participants who underwent closed-loop stimulation targeting theta oscillations in hippocampal networks. The data support an investigation into how closed-loop control of theta rhythms modulates human hippocampal network connectivity, encompassing pre- and post-stimulation evoked potentials, resting-state periods, and stimulation epochs (closed-loop and control). Electrode locations are provided in MNI152 2009c asymmetrical template space.","owner_user_id":15,"status":"active","github_repo":"nemarDatasets/on006065","concept_doi":"10.82901/nemar.on006065","latest_version_doi":"10.82901/nemar.on006065.v1.0.0","created_at":"2026-06-28 12:01:40","updated_at":"2026-08-19 00:55:24","zenodo_concept_id":null,"is_sandbox":0,"visibility":"public","ezid_status":"public","enrichment_json":"{\n  \"version\": \"2.0\",\n  \"pipeline_stage\": \"enriched\",\n  \"title\": \"TSS_iEEG\",\n  \"description\": \"This dataset comprises intracranial EEG (iEEG) recordings from 7 participants who underwent closed-loop stimulation targeting theta oscillations in hippocampal networks. The data support an investigation into how closed-loop control of theta rhythms modulates human hippocampal network connectivity, encompassing pre- and post-stimulation evoked potentials, resting-state periods, and stimulation epochs (closed-loop and control). Electrode locations are provided in MNI152 2009c asymmetrical template space.\",\n  \"methods_description\": \"Raw iEEG data were recorded in BrainVision format (vhdr, vmrk, eeg) and organized according to the BIDS iEEG specification. Each subject's data are segmented into pre-stimulation and post-stimulation evoked potentials, pre- and post-stimulation rest periods, closed-loop stimulation, and control stimulation. Electrode coordinates were registered to the MNI152 2009c asymmetrical template. Data were converted to BIDS using the FieldTrip data2bids converter.\",\n  \"license\": \"CC0\",\n  \"dataset_type\": \"raw\",\n  \"authors\": {\n    \"James Kragel\": {},\n    \"Joel Voss\": {}\n  },\n  \"keywords\": [\n    {\n      \"term\": \"intracranial EEG\"\n    },\n    {\n      \"term\": \"Hippocampus\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D006624\"\n    },\n    {\n      \"term\": \"Theta Rhythm\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D013826\"\n    },\n    {\n      \"term\": \"closed-loop stimulation\"\n    },\n    {\n      \"term\": \"brain-computer interface\"\n    },\n    {\n      \"term\": \"neural connectivity\"\n    }\n  ],\n  \"related_identifiers\": [\n    {\n      \"identifier\": \"https://github.com/nemarDatasets/on006065\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"https://nemar.org/dataset/on006065\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"10.18112/openneuro.ds006065\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsVersionOf\"\n    },\n    {\n      \"identifier\": \"10.18112/openneuro.ds006065.v1.0.0\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsDerivedFrom\"\n    }\n  ],\n  \"funding_references\": [\n    {\n      \"funder_name\": \"National Institute Of Neurological Disorders and Stroke\",\n      \"award_number\": \"R01NS113804\"\n    }\n  ],\n  \"resource_type_general\": \"Dataset\",\n  \"resource_type_specific\": \"iEEG Dataset\",\n  \"modalities\": [\n    \"ieeg\"\n  ],\n  \"sizes\": [\n    \"10.3 GB (136 files)\"\n  ],\n  \"formats\": [\n    \".eeg\",\n    \".json\",\n    \".md\",\n    \".tsv\",\n    \".vhdr\",\n    \".vmrk\",\n    \".yml\"\n  ],\n  \"source_hash\": \"a2677dabdbe94a5fb0a24bb254a31b7403734d7ae33d33b94234ece0f6c23883\"\n}","last_activity_at":"2026-06-28 12:01:40","source":"openneuro","source_id":"ds006065","subject_count":7,"modalities":"ieeg","age_min":null,"age_max":null,"file_size":10343284795,"total_files":254,"tasks":"cl,clcontrol,epcontrolpost,epcontrolpre,eppost,eppre,restcontrolpost,restcontrolpre,restpost,restpre","metadata_columns_error":null,"staleness_warn_stage":null,"staleness_admin_notified_at":null,"authors":"James Kragel, Joel Voss","license":"CC0","readme":"[![DOI](https://img.shields.io/badge/DOI-10.82901%2Fnemar.on006065-blue)](https://doi.org/10.82901/nemar.on006065)\n\n# iEEG Dataset: Theta-synchronized Stimulation of Human Hippocampal Networks\n\n## Information\nThis folder contains intracranial EEG (iEEG) data from **7 participants** undergoing closed-loop stimulation as part of a study on hippocampal network connectivity, as used in the following publication:  \n\n**Kragel et al., 2025, Nature Communications:**  \n*“Closed-loop control of theta oscillations enhances human hippocampal network connectivity”*  \n\nFor questions or further information, contact:  \n- **James Kragel:** [jkragel@uchicago.edu](mailto:jkragel@uchicago.edu)  \n- **Joel Voss:** [joelvoss@uchicago.edu](mailto:joelvoss@uchicago.edu)  \n\n---\n\n## License\nThis dataset is made available under the **Public Domain Dedication and License v1.0**.  \nFull text: [http://www.opendatacommons.org/licenses/pddl/1.0](http://www.opendatacommons.org/licenses/pddl/1.0)\n\n---\n\n## Dataset and Protocol\nThe data are organized according to the **Brain Imaging Data Structure (BIDS)** iEEG specification, a community-driven standard for organizing neurophysiology data along with its metadata.  \n\n### Structure\nEach subject folder contains the raw iEEG data for that subject, segmented into different periods of the stimulation protocol:\n- **Pre-stimulation evoked potentials**\n- **Post-stimulation evoked potentials**\n- **Pre-stimulation rest**\n- **Post-stimulation rest**\n- **Closed-loop stimulation**\n- **Control stimulation**\n\n---\n\n## Raw Data\nThe raw data are stored in **BrainVision format** (`vhdr`, `vmrk`, and `eeg` files). You can read these files into memory using the following tools:\n\n- **MATLAB:** [FieldTrip toolbox](https://www.fieldtriptoolbox.org/getting_started/eeg/brainvision/)  \n- **Python:** [`pybv` package](https://github.com/bids-standard/pybv)  \n\n### Electrode Coordinates\nElectrode coordinates are provided in **MNI space**, registered to the **MNI152 2009c asymmetrical template**.\n","bids_version":"1.8","sessions_count":null,"publish_date":null,"embedding_dirty":0,"license_tier":"public","zarr_status":"ready","zarr_converted_at":"2026-08-24 21:07:31","zarr_store_count":36,"zarr_index_etag":"253c237ee78a1392160cffca9ccf21d9","zarr_source_commit":"9cb58d82a2de48826dbd8df95912a74307a7143f","archive_status":"ready","archive_size":9550833303,"archive_retry_count":0,"records_status":"ready","archive_skip_reason":null,"zarr_errors":9,"zarr_failure_count":9,"zarr_deterministic":0,"zarr_failed_at":"2026-08-24 21:07:31","num_dataset_citations":0,"num_datapaper_citations":0,"n_channels":null,"electrode_system":null,"has_hed":0,"hed_version":null,"is_exemplar":0,"bytes_present":10343007794,"data_complete":1,"withdrawn_at":null,"withdrawn_reason":null,"archive_complete":null,"archive_absent_files":null,"archive_declared_files":null,"zarr_pool_breaks":0,"total_recording_duration":18847.128,"recording_duration_min":80,"recording_duration_max":3603,"recording_count":45,"recordings_unavailable":9,"recordings_measured":36,"channel_count_min":43,"channel_count_max":181,"sampling_frequency":null,"power_line_frequency":null,"eeg_reference":null,"placement_scheme":null,"sweep_stamps":"{\"enrichment_updated_at\":\"2026-08-19 00:55:15\",\"metadata_updated_at\":\"2026-08-19 00:55:23\",\"archive_checked_at\":\"2026-06-28 12:16:45\",\"zarr_checked_at\":null,\"records_checked_at\":\"2026-06-28 12:10:38\",\"citations_updated_at\":null,\"channel_montage_checked_at\":\"2026-06-28 23:53:09\",\"hed_checked_at\":\"2026-06-30 05:29:53\",\"data_checked_at\":\"2026-08-26 03:00:24\",\"availability_report_at\":\"2026-07-23 01:28:16\",\"recording_stats_at\":\"2026-09-02 11:33:35\",\"signal_defaults_at\":\"2026-09-02 12:43:03\"}","participants":7,"num_citations":0,"latest_version":"v1.0.0","zarr_verify_status":null,"zarr_verified_at":null,"owner_username":"nemarAdmin","owner_github":"nemarAdmin","file_size_formatted":"9.63 GB","zarr_data_failures":{"count":9,"detail_ref":"zarr/index.json","compacted_by":"migration_0074"},"zarr_index_url":"https://zarr.nemar.org/on006065/zarr/index.json","attestation_deposit_type":null,"attestation_key_status":null,"attestation_deidentified":null,"attestation_no_duplicate":null,"attestation_upstream_source":null,"attestation_accepted_at":null}}