{"dataset":{"id":"59732","dataset_id":"on004998","name":"Exploring the electrophysiology of Parkinson's disease - magnetoencephalography combined with deep brain recordings from the subthalamic nucleus. ","description":"This dataset comprises simultaneous magnetoencephalography (MEG) and subthalamic nucleus (STN) local field potential (LFP) recordings from externalized deep brain stimulation (DBS) patients with Parkinson's disease. Recordings were performed both with and without dopaminergic medication, across resting-state and movement conditions (forearm extension hold and self-paced fist-clenching). The study aims to elucidate the neurophysiology of basal ganglia-cortex loops and how they are modulated by movement and medication status.","owner_user_id":15,"status":"active","github_repo":"nemarDatasets/on004998","concept_doi":"10.82901/nemar.on004998","latest_version_doi":"10.82901/nemar.on004998.v1.0.0","created_at":"2026-06-26 03:01:43","updated_at":"2026-08-19 02:13:53","zenodo_concept_id":null,"is_sandbox":0,"visibility":"public","ezid_status":"public","enrichment_json":"{\n  \"version\": \"2.0\",\n  \"pipeline_stage\": \"validated\",\n  \"title\": \"Exploring the electrophysiology of Parkinson's disease - magnetoencephalography combined with deep brain recordings from the subthalamic nucleus. \",\n  \"description\": \"This dataset comprises simultaneous magnetoencephalography (MEG) and subthalamic nucleus (STN) local field potential (LFP) recordings from externalized deep brain stimulation (DBS) patients with Parkinson's disease. Recordings were performed both with and without dopaminergic medication, across resting-state and movement conditions (forearm extension hold and self-paced fist-clenching). The study aims to elucidate the neurophysiology of basal ganglia-cortex loops and how they are modulated by movement and medication status.\",\n  \"methods_description\": \"Data were collected via simultaneous MEG and STN LFP recordings from externalized DBS patients under two medication states (MedOn/MedOff). Recording sessions included resting-state periods and movement tasks: static forearm extension (hold) and self-paced fist-clenching (move), each preceded by 5 minutes of rest, with pauses during the movement segments. Some patients underwent resting-state recordings only.\",\n  \"license\": \"CC0\",\n  \"dataset_type\": \"raw\",\n  \"authors\": {\n    \"Fayed Rassoulou\": {},\n    \"Alexandra Steina\": {},\n    \"Christian J. Hartmann\": {},\n    \"Jan Vesper\": {},\n    \"Markus Butz\": {},\n    \"Alfons Schnitzler\": {},\n    \"Jan Hirschmann\": {}\n  },\n  \"keywords\": [\n    {\n      \"term\": \"Parkinson Disease\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D010300\"\n    },\n    {\n      \"term\": \"Magnetoencephalography\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D015225\"\n    },\n    {\n      \"term\": \"Deep Brain Stimulation\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D046690\"\n    },\n    {\n      \"term\": \"Subthalamic Nucleus\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D020531\"\n    },\n    {\n      \"term\": \"local field potentials\"\n    },\n    {\n      \"term\": \"basal ganglia-cortex loops\"\n    },\n    {\n      \"term\": \"dopaminergic medication\"\n    }\n  ],\n  \"related_identifiers\": [\n    {\n      \"identifier\": \"10.1038/s41597-024-03768-1\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"https://github.com/nemarDatasets/on004998\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"10.21105/joss.01896\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"References\"\n    },\n    {\n      \"identifier\": \"10.1038/sdata.2018.110\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"References\"\n    },\n    {\n      \"identifier\": \"10.18112/openneuro.ds004998.v1.2.2\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsDerivedFrom\"\n    },\n    {\n      \"identifier\": \"https://nemar.org/dataset/on004998\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    }\n  ],\n  \"funding_references\": [\n    {\n      \"funder_name\": \"The project was funded by ERA-NET Neuron for 3 years.\"\n    },\n    {\n      \"funder_name\": \"ERA-NET Neuron\"\n    }\n  ],\n  \"resource_type_general\": \"Dataset\",\n  \"resource_type_specific\": \"MEG Dataset\",\n  \"modalities\": [\n    \"meg\"\n  ],\n  \"sizes\": [\n    \"173.7 GB (186 files)\"\n  ],\n  \"formats\": [\n    \".fif\",\n    \".json\",\n    \".mat\",\n    \".md\",\n    \".tsv\",\n    \".yml\"\n  ],\n  \"source_hash\": \"6aaa9e4a41cbc29ae880797a154e3a2cea4a08dc7bbc7d9e68adce4517ae0150\"\n}","last_activity_at":"2026-06-26 03:01:43","source":"openneuro","source_id":"ds004998","subject_count":20,"modalities":"meg","age_min":48,"age_max":76,"file_size":173726033459,"total_files":642,"tasks":"HoldL,HoldR,MoveL,MoveR,Rest,noise","metadata_columns_error":null,"staleness_warn_stage":null,"staleness_admin_notified_at":null,"authors":"Fayed Rassoulou, Alexandra Steina, Christian J. Hartmann, Jan Vesper, Markus Butz, Alfons Schnitzler, Jan Hirschmann","license":"CC0","readme":"[![DOI](https://img.shields.io/badge/DOI-10.82901%2Fnemar.on004998-blue)](https://doi.org/10.82901/nemar.on004998)\n\nThis dataset contains data from externalized DBS patients undergoing simultaneous MEG - STN LFP recordings with (MedOn) and without (MedOn) dopaminergic medication. It has two movement conditions: 1) 5 min of rest followed by static forearm extension (hold) and 2) 5 min of rest followed by self-paced fist-clenching (move). The movement parts contain pauses. Some patients were recorded in resting-state only (rest). The project aimed to understand the neurophysiology of basal ganglia-cortex loops and its modulation by movement and medication.\n\nCode for quickly start is available here:\nhttps://github.com/Fayed-Rsl/RHM_preprocessing\n\nReferences\n----------\nRassoulou, F., Steina, A., Hartmann, C. J., Vesper, J., Butz, M., Schnitzler, A., & Hirschmann, J. (2024). Exploring the electrophysiology of Parkinson's disease with magnetoencephalography and deep brain recordings. Scientific data, 11(1), 889. https://doi.org/10.1038/s41597-024-03768-1\n\nAppelhoff, S., Sanderson, M., Brooks, T., Vliet, M., Quentin, R., Holdgraf, C., Chaumon, M., Mikulan, E., Tavabi, K., Höchenberger, R., Welke, D., Brunner, C., Rockhill, A., Larson, E., Gramfort, A. and Jas, M. (2019). MNE-BIDS: Organizing electrophysiological data into the BIDS format and facilitating their analysis. Journal of Open Source Software 4: (1896). https://doi.org/10.21105/joss.01896\n\nNiso, G., Gorgolewski, K. J., Bock, E., Brooks, T. L., Flandin, G., Gramfort, A., Henson, R. N., Jas, M., Litvak, V., Moreau, J., Oostenveld, R., Schoffelen, J., Tadel, F., Wexler, J., Baillet, S. (2018). MEG-BIDS, the brain imaging data structure extended to magnetoencephalography. Scientific Data, 5, 180110. https://doi.org/10.1038/sdata.2018.110\n","bids_version":"1.6.0","sessions_count":1,"publish_date":null,"embedding_dirty":0,"license_tier":"public","zarr_status":"pending","zarr_converted_at":"2026-06-30 07:11:04","zarr_store_count":18,"zarr_index_etag":"00d5a632794be69627b7611ef0a19253","zarr_source_commit":"96e38cfbbc0015a80fefc56810ba4b125c8dd66b","archive_status":null,"archive_size":null,"archive_retry_count":0,"records_status":"ready","archive_skip_reason":"dataset 161.8 GB exceeds 100.0 GB archive limit; use direct download","zarr_errors":null,"zarr_failure_count":null,"zarr_deterministic":null,"zarr_failed_at":null,"num_dataset_citations":4,"num_datapaper_citations":10,"n_channels":null,"electrode_system":null,"has_hed":0,"hed_version":null,"is_exemplar":0,"bytes_present":173722776685,"data_complete":1,"withdrawn_at":null,"withdrawn_reason":null,"archive_complete":null,"archive_absent_files":null,"archive_declared_files":null,"zarr_pool_breaks":null,"total_recording_duration":null,"recording_duration_min":null,"recording_duration_max":null,"recording_count":null,"recordings_unavailable":null,"recordings_measured":null,"channel_count_min":null,"channel_count_max":null,"sampling_frequency":null,"power_line_frequency":null,"eeg_reference":null,"placement_scheme":null,"sweep_stamps":"{\"enrichment_updated_at\":\"2026-08-19 02:13:42\",\"metadata_updated_at\":\"2026-08-19 02:13:52\",\"archive_checked_at\":\"2026-06-26 03:22:36\",\"zarr_checked_at\":null,\"records_checked_at\":\"2026-06-26 03:23:09\",\"citations_updated_at\":\"2026-09-08 03:00:49\",\"channel_montage_checked_at\":null,\"hed_checked_at\":\"2026-06-30 05:09:54\",\"data_checked_at\":\"2026-08-17 03:01:00\",\"availability_report_at\":\"2026-07-23 01:22:15\",\"recording_stats_at\":null,\"signal_defaults_at\":\"2026-09-02 12:23:24\"}","participants":20,"num_citations":14,"latest_version":"v1.0.0","zarr_verify_status":null,"zarr_verified_at":null,"owner_username":"nemarAdmin","owner_github":"nemarAdmin","file_size_formatted":"162 GB","zarr_data_failures":null,"zarr_index_url":null,"attestation_deposit_type":null,"attestation_key_status":null,"attestation_deidentified":null,"attestation_no_duplicate":null,"attestation_upstream_source":null,"attestation_accepted_at":null}}