{"dataset":{"id":"54511","dataset_id":"on003876","name":"Epilepsy-iEEG-Interictal-Multicenter-Dataset","description":"A multicenter interictal intracranial electroencephalography (iEEG) dataset from patients with epilepsy, comprising de-identified recordings from six clinical centers: the National Institutes of Health, Johns Hopkins Hospital, University of Miami Florida Jackson Memorial Hospital, Kansas University Medical Center, University of Pittsburgh Medical Center, and Cleveland Clinic (with data from the latter three centers restricted due to institutional data sharing limitations). The dataset includes annotations of sleep and awake states and features processed derivatives including source-sink connectivity analysis and high-frequency oscillation detection. This resource supports investigation of electrophysiological markers of the epileptogenic zone.","owner_user_id":15,"status":"active","github_repo":"nemarDatasets/on003876","concept_doi":"10.82901/nemar.on003876","latest_version_doi":"10.82901/nemar.on003876.v1.0.0","created_at":"2026-06-22 20:01:16","updated_at":"2026-07-10 22:21:58","zenodo_concept_id":null,"is_sandbox":0,"visibility":"public","ezid_status":"public","enrichment_json":"{\n  \"version\": \"2.0\",\n  \"pipeline_stage\": \"enriched\",\n  \"title\": \"Epilepsy-iEEG-Interictal-Multicenter-Dataset\",\n  \"description\": \"A multicenter interictal intracranial electroencephalography (iEEG) dataset from patients with epilepsy, comprising de-identified recordings from six clinical centers: the National Institutes of Health, Johns Hopkins Hospital, University of Miami Florida Jackson Memorial Hospital, Kansas University Medical Center, University of Pittsburgh Medical Center, and Cleveland Clinic (with data from the latter three centers restricted due to institutional data sharing limitations). The dataset includes annotations of sleep and awake states and features processed derivatives including source-sink connectivity analysis and high-frequency oscillation detection. This resource supports investigation of electrophysiological markers of the epileptogenic zone.\",\n  \"methods_description\": \"Intracranial EEG recordings were collected from patients with epilepsy across multiple clinical centers. Data were de-identified and organized according to BIDS standards using MNE-BIDS. Processed derivatives include source-sink connectivity analysis and high-frequency oscillation (HFO) detection using both RMS and Hilbert transform methods.\",\n  \"license\": \"CC0\",\n  \"dataset_type\": \"raw\",\n  \"authors\": {\n    \"Gunnarsdottir, Kristin\": {\n      \"orcid\": \"0000-0002-9278-3844\"\n    },\n    \"Li, Adam\": {\n      \"orcid\": \"0000-0001-8421-365X\"\n    },\n    \"Smith, Rachel\": {},\n    \"Kang, Joon\": {},\n    \"Korzeniewska, Anna\": {},\n    \"Crone, Nathan\": {\n      \"orcid\": \"0000-0001-7950-2617\"\n    },\n    \"Rouse, Adam\": {\n      \"orcid\": \"0000-0003-3785-1442\"\n    },\n    \"Cheng, Jennifer\": {},\n    \"Kinsman, Michael\": {},\n    \"Landazuri, Patrick\": {},\n    \"Uysal, Utku\": {},\n    \"Ulloa, Carol\": {},\n    \"Cameron, Nathaniel\": {},\n    \"Cajigas, Iahn\": {\n      \"orcid\": \"0000-0002-5808-453X\"\n    },\n    \"Jagid, Jonathan\": {\n      \"orcid\": \"0000-0001-6015-5360\"\n    },\n    \"Kanner, Andres\": {},\n    \"Elarjani, Turki\": {},\n    \"Bicchi, Manuel\": {},\n    \"Inati, Sara\": {\n      \"orcid\": \"0000-0002-7587-5085\"\n    },\n    \"Zaghloul, Kareem\": {\n      \"orcid\": \"0000-0001-8575-3578\"\n    },\n    \"Boerwinkle, Varina\": {},\n    \"Wyckoff, Sarah\": {},\n    \"Barot, Niravkumar\": {},\n    \"Gonzalez-Martinez, Jorge\": {},\n    \"Sarma, Sridevi\": {}\n  },\n  \"keywords\": [\n    {\n      \"term\": \"intracranial EEG\"\n    },\n    {\n      \"term\": \"Epilepsy\",\n      \"subject_scheme\": \"MeSH\",\n      \"value_uri\": \"http://id.nlm.nih.gov/mesh/D004827\"\n    },\n    {\n      \"term\": \"seizure onset zone\"\n    },\n    {\n      \"term\": \"high-frequency oscillations\"\n    },\n    {\n      \"term\": \"source-sink connectivity\"\n    },\n    {\n      \"term\": \"interictal activity\"\n    },\n    {\n      \"term\": \"sleep\"\n    },\n    {\n      \"term\": \"awake state\"\n    },\n    {\n      \"term\": \"multicenter\"\n    },\n    {\n      \"term\": \"BIDS\"\n    },\n    {\n      \"term\": \"de-identified\"\n    },\n    {\n      \"term\": \"seizure\"\n    }\n  ],\n  \"related_identifiers\": [\n    {\n      \"identifier\": \"https://github.com/nemarDatasets/on003876\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"https://nemar.org/dataexplorer/detail?dataset_id=on003876\",\n      \"identifier_type\": \"URL\",\n      \"relation_type\": \"IsDescribedBy\"\n    },\n    {\n      \"identifier\": \"10.1038/s41593-021-00901-w\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsReferencedBy\"\n    },\n    {\n      \"identifier\": \"10.1101/2021.10.15.464594\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsReferencedBy\"\n    },\n    {\n      \"identifier\": \"10.21105/joss.01896\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"References\"\n    },\n    {\n      \"identifier\": \"10.1038/s41597-019-0105-7\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"References\"\n    },\n    {\n      \"identifier\": \"10.18112/openneuro.ds003029\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsSupplementedBy\"\n    },\n    {\n      \"identifier\": \"10.18112/openneuro.ds003876.v1.0.2\",\n      \"identifier_type\": \"DOI\",\n      \"relation_type\": \"IsDerivedFrom\"\n    }\n  ],\n  \"funding_references\": [\n    {\n      \"funder_name\": \"ARCS Scholarship\"\n    },\n    {\n      \"funder_name\": \"Whitaker Fellowship\"\n    },\n    {\n      \"funder_name\": \"Chateaubriand Fellowship\"\n    },\n    {\n      \"funder_name\": \"NIH\",\n      \"award_number\": \"T32 EB003383\"\n    },\n    {\n      \"funder_name\": \"NSF\",\n      \"award_number\": \"DGE-1746891\"\n    },\n    {\n      \"funder_name\": \"NIH\",\n      \"award_number\": \"R21 NS103113\"\n    },\n    {\n      \"funder_name\": \"NSF\",\n      \"award_number\": \"1055560\"\n    },\n    {\n      \"funder_name\": \"Burroughs Wellcome Fund\",\n      \"award_number\": \"1007274\"\n    }\n  ],\n  \"resource_type_general\": \"Dataset\",\n  \"resource_type_specific\": \"iEEG Dataset\",\n  \"modalities\": [\n    \"ieeg\"\n  ],\n  \"sizes\": [\n    \"5.5 GB (199 files)\"\n  ],\n  \"formats\": [\n    \".edf\",\n    \".json\",\n    \".mat\",\n    \".md\",\n    \".tsv\",\n    \".xlsx\",\n    \".yml\"\n  ],\n  \"source_hash\": \"cf7df5886482886e2ed887e16447f42f9eb4874d6674790d400648d4180c25b0\"\n}","last_activity_at":"2026-06-22 20:01:16","source":"openneuro","source_id":"ds003876","subject_count":39,"modalities":"ieeg","age_min":16,"age_max":68,"file_size":5520762343,"total_files":493,"tasks":"interictal,interictalasleep,interictalawake","metadata_columns_error":null,"staleness_warn_stage":null,"staleness_admin_notified_at":null,"authors":"Gunnarsdottir, Kristin, Li, Adam, Smith, Rachel, Kang, Joon, Korzeniewska, Anna, Crone, Nathan, Rouse, Adam, Cheng, Jennifer, Kinsman, Michael, Landazuri, Patrick, Uysal, Utku, Ulloa, Carol, Cameron, Nathaniel, Cajigas, Iahn, Jagid, Jonathan, Kanner, Andres, Elarjani, Turki, Bicchi, Manuel, Inati, Sara, Zaghloul, Kareem, Boerwinkle, Varina, Wyckoff, Sarah, Barot, Niravkumar, Gonzalez-Martinez, Jorge, Sarma, Sridevi","license":"CC0","readme":"[![DOI](https://img.shields.io/badge/DOI-10.82901%2Fnemar.on003876-blue)](https://doi.org/10.82901/nemar.on003876)\n\nEpilepsy Interictal Dataset\n=====================\n\nThis dataset was updated and prepared for release as part of a manuscript by Bernabei & Li et al. (in preparation). A subset of the data has been featured in [1] and [2].\n\nSummary\n-------------\n\nThis dataset comprises of de-identified subjects with interictal iEEG recordings possibly with sleep or awake state annotated. The subjects come from the following centers:\n\n- National Institute of Health (NIH)\n- Johns Hopkins Hospital (JHH)\n- University of Miami Florida Jackson Memorial Hospital (UMF)\n\nIn the actual study, there is also data from Kansas University Medical Center (KUMC), University of Pittsburgh Medical Center and Cleveland Clinic, whose data is not shared due to restrictions imposed by the centers there.\n\nSome subjects, namely with the ``rns`` prefix in their subject ID were treated with RNS rather then surgical resection/ablation.\n\nDerivatives\n----------------\n\nThe processed data corresponding to the ``source-sink`` analysis and ``hfo`` comparisons are shown in the ``derivatives/`` folder. The HFO analysis consists of two folders, one is an RMS detector and the other is a Hilbert detector. See the paper for details.\n\nTies to Other Datasets\n--------------------------------\n\nNIH ``pt1, pt2, pt3``, JHH ``jh103, jh105`` subjects are also datasets in ``https://openneuro.org/datasets/ds003029``, where the ictal snapshots are stored. These correspond to the following:\n\n- pt1: pt01\n- pt2: pt2\n- pt3: pt3\n- jh103: jh103\n- jh105: jh105\n\nMoreover, the cclinic subjects are used in that study, but not open-access due to data sharing limitations at Cleveland Clinic. Those ictal datasets were analyzed in https://www.nature.com/articles/s41593-021-00901-w. \n\nReferences\n----------------\n\n[1] Li, A., Huynh, C., Fitzgerald, Z. et al. Neural fragility as an EEG marker of the seizure onset zone. Nat Neurosci 24, 1465–1474 (2021). https://doi.org/10.1038/s41593-021-00901-w\n\n[2] Kristin M. Gunnarsdottir, Adam Li, Rachel J. Smith, Joon-Yi Kang, Nathan E. Crone, Anna Korzeniewska, Adam Rouse, Nathaniel Cameron, Iahn Cajigas, Sara Inati, Kareem A. Zaghloul, Varina L. Boerwinkle, Sarah Wyckoff, Nirav Barot, Jorge Gonzalez-Martinez, Sridevi V. Sarma. Source-sink connectivity: a novel resting-state EEG marker of the epileptogenic zone. bioRxiv 2021.10.15.464594; doi: https://doi.org/10.1101/2021.10.15.464594\n\n[3] Appelhoff, S., Sanderson, M., Brooks, T., Vliet, M., Quentin, R., Holdgraf, C., Chaumon, M., Mikulan, E., Tavabi, K., Höchenberger, R., Welke, D., Brunner, C., Rockhill, A., Larson, E., Gramfort, A. and Jas, M. (2019). MNE-BIDS: Organizing electrophysiological data into the BIDS format and facilitating their analysis. Journal of Open Source Software 4: (1896). https://doi.org/10.21105/joss.01896\n\n[4] Holdgraf, C., Appelhoff, S., Bickel, S., Bouchard, K., D'Ambrosio, S., David, O., … Hermes, D. (2019). iEEG-BIDS, extending the Brain Imaging Data Structure specification to human intracranial electrophysiology. Scientific Data, 6, 102. https://doi.org/10.1038/s41597-019-0105-7\n\n","bids_version":"1.6.0","sessions_count":1,"publish_date":null,"embedding_dirty":0,"license_tier":"public","zarr_status":"ready","zarr_converted_at":"2026-08-04 14:15:35","zarr_store_count":47,"zarr_index_etag":"4c6d2e5bb1a7f2d22c8d865b73ec7398","zarr_source_commit":"97a3169f87ac3d738ee1932411185dfdc7b357d6","archive_status":"ready","archive_size":4642323480,"archive_retry_count":0,"records_status":"ready","archive_skip_reason":null,"zarr_errors":7,"zarr_failure_count":4,"zarr_deterministic":0,"zarr_failed_at":"2026-08-04 14:15:35","num_dataset_citations":5,"num_datapaper_citations":0,"n_channels":null,"electrode_system":null,"has_hed":0,"hed_version":null,"is_exemplar":0,"bytes_present":5503907728,"data_complete":1,"withdrawn_at":null,"withdrawn_reason":null,"archive_complete":null,"archive_absent_files":null,"archive_declared_files":null,"zarr_pool_breaks":null,"total_recording_duration":14366.968078078078,"recording_duration_min":47.171171171171174,"recording_duration_max":1070.172,"recording_count":51,"recordings_unavailable":4,"recordings_measured":47,"channel_count_min":46,"channel_count_max":193,"sampling_frequency":null,"power_line_frequency":null,"eeg_reference":null,"placement_scheme":null,"sweep_stamps":"{\"enrichment_updated_at\":\"2026-06-22 20:09:44\",\"metadata_updated_at\":\"2026-06-22 20:09:44\",\"archive_checked_at\":\"2026-06-22 20:14:32\",\"zarr_checked_at\":null,\"records_checked_at\":\"2026-06-22 20:11:14\",\"citations_updated_at\":\"2026-09-08 03:00:50\",\"channel_montage_checked_at\":\"2026-06-28 23:16:49\",\"hed_checked_at\":\"2026-06-30 04:48:57\",\"data_checked_at\":\"2026-08-04 03:00:16\",\"availability_report_at\":\"2026-07-23 01:15:44\",\"recording_stats_at\":\"2026-09-02 11:32:35\",\"signal_defaults_at\":\"2026-09-02 12:04:34\"}","participants":39,"num_citations":5,"latest_version":"v1.0.0","zarr_verify_status":null,"zarr_verified_at":null,"owner_username":"nemarAdmin","owner_github":"nemarAdmin","file_size_formatted":"5.14 GB","zarr_data_failures":{"count":4,"detail_ref":"zarr/index.json","compacted_by":"migration_0074"},"zarr_index_url":"https://zarr.nemar.org/on003876/zarr/index.json","attestation_deposit_type":null,"attestation_key_status":null,"attestation_deidentified":null,"attestation_no_duplicate":null,"attestation_upstream_source":null,"attestation_accepted_at":null}}